Crystal Equation
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Associate I, Technical Development Operations
Summary:
This position reports to the Lead, Technical Department Operations in the Technical Development Department within our Cell and Gene Therapy Research Division. The associate will participate in upstream and downstream areas of AAV development and production within process development and the pilot plant for gene therapy programs and processes. This position will be located in South San Francisco, CA.
Responsibilities:
Required Qualifications:
Preferred Qualifications:
Pay range is $30 - $35 per hour with full benefits available, including paid time off, medical/dental/vision/life insurance, 401K, parental leave, and more. Our compensation reflects the cost of labor across several US geographic markets. Pay is based on several factors including market location and may vary depending on job-related knowledge, skills, and experience.
THE PROMISES WE MAKE:
At Crystal Equation, we empower people and advance technology initiatives by building trust. Your recruiter will prep you for the interview, obtain feedback, guide you through any necessary paperwork and provide everything you need for a successful start. We will serve to empower you along the way and provide the path for your professional journey.
For more information regarding our Privacy Policy, please visit crystalequation.com/privacy.
Associate I, Technical Development Operations
100 Kimball Way San Francisco, CA 94080 US
Posted: 10/23/2025
2025-10-23
2025-12-10
Job Number: 41451
Job Description
Associate I, Technical Development Operations
Summary:
This position reports to the Lead, Technical Department Operations in the Technical Development Department within our Cell and Gene Therapy Research Division. The associate will participate in upstream and downstream areas of AAV development and production within process development and the pilot plant for gene therapy programs and processes. This position will be located in South San Francisco, CA.
Responsibilities:
- Perform all operations as directed per internal policies and other requirements.
- Execute experiments for cell culture and transfections in shake flasks and various scales of bioreactors
- Maintain seed train cell cultures, from vial thaw through expansions and cell banking
- Perform cell culture harvest operations, ensuring minimal loss of product
- Support downstream purification unit operations (such as chromatography, clarification, tangential flow filtration, sterile filtration, column packing, etc.)
- Operate production equipment, including inspection, set up, processing, and cleaning
- Establish operating equipment specifications and improve operational techniques
- Execute corrective measures addressing any issues in a timely manner
- Attend safety meetings and follow all safety procedures as defined, including maintaining a safe work environment for both self and colleagues. Execute corrective measures addressing any issues in a timely manner
- Ability to contribute to process improvement plans and help drive to completion
- Conduct operations in a collaborative, team environment with a positive attitude to accomplish goals
- Assist with process development experiments following defined experimental plans for non-GMP supply
- Document preparation and maintenance for process development and research grade AAV production operations.
- Maintain digital records of all research production activities using in-house systems and shared digital document repositories.
- Follow laboratory safety procedures.
- Other duties as assigned
- This is a lab and office-centric position that requires onsite work.
Required Qualifications:
- BS in Life Science or Engineering or equivalent experience
- Associate I: 0-2+ years of experience working in a pharmaceutical/biologics lab or manufacturing environment
- Display understanding of upstream and/or downstream process theory (i.e., Cell Culture, Harvest, Tangential Flow Filtration, Column Chromatography) and equipment operation
- Strong communicator with ability to work effectively both independently and as part of a team
- Demonstrated experience in maintaining detailed records and ability to assist in document revisions
- Strong computer skills including MS Office (Word, Excel, PowerPoint)
- Effective problem-solving skills
- Available to work outside of normal business hours and/or overtime as required (occasional weekend work)
Preferred Qualifications:
- Experience in cell culture and/or protein purification
- Technical understanding of a biotech manufacturing facility
- Experience with single-use technologies
- Working knowledge of disposable manufacturing methodology such as the use of sterile bags with tubing and tubing welders
- Ability to multi-task, be flexible and to thrive in a fast-paced environment, as well as the capacity to handle uncertainty and changing priorities
Pay range is $30 - $35 per hour with full benefits available, including paid time off, medical/dental/vision/life insurance, 401K, parental leave, and more. Our compensation reflects the cost of labor across several US geographic markets. Pay is based on several factors including market location and may vary depending on job-related knowledge, skills, and experience.
THE PROMISES WE MAKE:
At Crystal Equation, we empower people and advance technology initiatives by building trust. Your recruiter will prep you for the interview, obtain feedback, guide you through any necessary paperwork and provide everything you need for a successful start. We will serve to empower you along the way and provide the path for your professional journey.
For more information regarding our Privacy Policy, please visit crystalequation.com/privacy.
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